Everyone Healthy Library
Avascular Necrosis
Also Known As: Osteonecrosis
Condition / disease reference page from the Everyone Healthy database.
Connected health information
Explore this condition in a clear order
Linked signs and symptoms
4Each sign/symptom opens its own page and links back to related conditions.
Linked drugs / medications
0No linked drugs are listed yet.
Treatments, therapies and supportive options
24Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Medical therapy
10- ArthroplastyWeakly in Favour(Low Evidence)
- Arthroplasty or HemiarthroplastyWeakly in Favour(Low Evidence)
- Bone Core DecompressionWeakly in Favour(Low Evidence)
- Bone Reshaping (Osteotomy)Weakly in Favour(Low Evidence)
- Bone Transplant (Graft)Weakly in Favour(Low Evidence)
- DebridementWeakly in Favour(Low Evidence)
- Free Vascular Fibular Graft (FVFG)Weakly in Favour(Low Evidence)
- Joint ImmobilizationWeakly in Favour(Low Evidence)
- OsteotomyWeakly in Favour(Low Evidence)
- Total Joint ReplacementWeakly in Favour(Low Evidence)
Lifestyle changes
2Behavioural changes
2Alternative and complementary therapies
1Linked diagnostic tests and investigations
7These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
Biological and test markers
8This visual map uses existing EH database links to show biological agents and lab markers reported as increased, decreased, or associated with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
7- Alpha-2-Globulin (Blood, Serum)Reference range exampleAll: 0.6–1 gm/dLLinked diagnostic tests1Protein Electrophoresis (Blood, Serum Protein)
- EosinophilsReference range exampleAdult ( > 16y): 0–3 %; 0–3 %Linked diagnostic tests3Differential White Blood Cell Count Tests, Eosinophil Differential Of Total WBC
- Erythrocyte Sedimentation RateReference range exampleAdult ( > 16y), Female: 0–20 mm/Hr; Adult ( > 16y), Male: 0–15 mm/HrLinked diagnostic tests1erythrocyte Sedimentation Rate (ESR)
- haptoglobin (Hp)Reference range example45–200 mg/dLLinked diagnostic tests1haptoglobin (Hp) concentration
- Histidine (Urine)Reference range exampleChild (0 - 16y): 500–7,300 µmol/L; Adult ( > 16y): 5,000–16,000 µmol/LLinked diagnostic tests1Urine Amino Acid Concentration
- Segmented NeutrophilsReference range exampleAdult ( > 16y): 50–62 %; Adult ( > 16y): 2,500–8,000 mm3Linked diagnostic tests2Differential White Blood Cell Count Tests, Neutrophil Absolute Count
- White Blood Cell (WBC)Reference range exampleAdult ( > 16y): 4.5–10.5 million/mL; Adult ( > 16y): 3.2–10 million/mLLinked diagnostic tests1White Blood Cell (WBC) Count
Often decreased
1Other associated markers
0No markers in this group.
Introduction / full article
Avascular Necrosis
Avascular Necrosis
Avascular necrosis (otherwise known as osteonecrosis) is the death of a bone segment due to inadequate blood supply. In the absence of blood, the bone’s tissue dies, leading to its collapse. This can occur either due to an injury or spontaneously. In the latter case, it is often the result of a blockage in the artery which feeds the area.
The condition is characterised by pain in the affected joint, and a subsequently limited range of its motion. The incidence of avascular necrosis has been linked to smoking, and excessive consumption of alcohol and drugs.