Everyone Healthy Library
Cystic Fibrosis
Also Known As: Fibrocystic Disease of the Pancreas; Mucoviscidosis
Condition / disease reference page from the Everyone Healthy database.
Connected health information
Explore this condition in a clear order
Condition overview
Attributes
Commonalityis common
Linked signs and symptoms
15Each sign/symptom opens its own page and links back to related conditions.
- Absence or Loss of Menstruation (Amenorrhoea)
- Arthritis
- Cough Chronic
- Digital Clubbing
- Growth Impairment or Stunted
- Infertility
- Intestinal obstruction (Ileus)
- Malnutrition
- Meconium Ileus (Failure of Newborn Infant to Past First Stools)
- Newborn Failure to Gain Weight
- Osteoporosis (Reduced Bone Density)
- Rectal Prolapse
- Sinus Congestion
- Skin Bluish Coloration (Cyanosis)
- Wheezing
Linked drugs / medications
3Medication information is educational only. A doctor or pharmacist should advise whether any medicine is appropriate.
Treatments, therapies and supportive options
26Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Surgery
2Medical therapy
6- Assisted ReproductionWeakly in Favour(Low Evidence)
- CFTR Gene TherapyWeakly in Favour(Low Evidence)
- Embryo TransferWeakly in Favour(Low Evidence)
- Intracytoplasmic Sperm InjectionWeakly in Favour(Low Evidence)
- Liver TransplantationWeakly in Favour(Low Evidence)
- Ventilatory SupportWeakly in Favour(Low Evidence)
Lifestyle changes
4Behavioural changes
1Alternative and complementary therapies
1Alternative medicine
1Vitamins and minerals
4Vitamins
2Linked diagnostic tests and investigations
25These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
- 2,3 Diphosphoglycerate (2,3-DPG) Concentration
- amniotic Fluid Test (AFT)
- Blood pH Test
- Blood Tests
- Chorionic Villus Sampling (CVS)
- Chorionic Villus Sampling (CVS)
- Computerized Tomography (CT) Scan
- Dual Energy X-Ray Absorptiometry (DXA)
- Fecal Chymotrypsin Concentration
- Fecal Fat Determination (Fat Absorption Test, Fecal Fat Stain)
- Gallium Scan
- Glucagon Concentration Test
- Intravenous Pyelogram (IVP)
- Lactose Tolerance Test
- Neurological Examinations
- Potassium Concentration (K, Blood)
- Protein Electrophoresis (Blood, Serum Protein)
- pulmonary Artery Catheter
- Spirometry
- Spirometry
- Sputum Test Culture
- Sweat Testing
- Sweat Testing
- Urine 5-Hydroxindoleacetic Acid Concentration
- Urine Specific Gravity (SG)
Biological and test markers
14This visual map uses existing EH database links to show biological agents and lab markers reported as increased, decreased, or associated with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
8- 2,3 Diphosphoglycerate (2,3-DPG)Reference range exampleAdult ( > 16y): 10.5–14 µmol/gLinked diagnostic tests12, 3 Diphosphoglycerate (2
- Abnormal Genetic or Biochemical MarkersReference range exampleAdult ( > 16y), Female: 0–1 Not PresentLinked diagnostic tests1Chorionic Villus Sampling (CVS)
- Blood pHReference range exampleAll: 7.35–7.45Linked diagnostic tests1Blood pH Test
- Chloride (Sweat, Cl)Reference range exampleChild (0 - 16y): 0–50 mEq/LLinked diagnostic tests1Sweat Testing
- Fecal FatReference range exampleAll: 1,000–7,000 mg/24hrsLinked diagnostic tests1Fecal Fat Determination (Fat Absorption Test, Fecal Fat Stain)
- Gamma Globulin (Blood, Serum)Reference range exampleAll: 0.8–1.7 gm/dLLinked diagnostic tests1Protein Electrophoresis (Blood, Serum Protein)
- Sodium (Na, Sweat)Reference range exampleChild (0 - 16y): 70–90 mEq/LLinked diagnostic tests1Sweat Testing
- Urine 5-Hydroxindoleacetic AcidReference range exampleAdult ( > 16y): 2–8 mg/24hrsLinked diagnostic tests1Urine 5-Hydroxindoleacetic Acid Concentration
Often decreased
6- Fecal ChymotrypsinReference range exampleAll: 75–1,200Linked diagnostic tests1Fecal Chymotrypsin Concentration
- Forced Expiratory Flow Between 25% and 75% of FVC (FEF25-75)Reference range exampleAll: 60–100 %Linked diagnostic tests1Spirometry
- GlucagonReference range exampleChild (0 - 16y): 0–147 pg/mL; Adult ( > 16y): 20–110 pg/mLLinked diagnostic tests1Glucagon Concentration Test
- Increase in Glucose ConcentrationReference range exampleAdult ( > 16y): 20–60 mg/dLLinked diagnostic tests1Lactose Tolerance Test
- Potassium (K, Blood)AbbreviationKReference range exampleInfant (0 - 1y): 4.1–5.3 mEq/L; Child (0 - 16y): 3.4–4.7 mEq/LLinked diagnostic tests1Potassium Concentration (K, Blood)
- Urine Specific Gravity (SG)Reference range exampleAdult ( > 16y): 1.005–1.03Linked diagnostic tests1Urine Specific Gravity (SG)
Other associated markers
0No markers in this group.
Introduction / full article
Cystic Fibrosis
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Turmeric [1, 2, 3, 4, 5, 6, 7]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor (Early laboratory studies show that turmeric may be of benefit in the treatment of cystic fibrosis. However, further studies are needed)
Grade of Evidence: low quality of evidence
Vitamin A Supplement [8]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin A supplements are able to help treat cystic fibrosis. More studies needed)
Grade of Evidence: Very low quality of evidence
Vitamin D Supplement [9, 10, 11]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor (Early studies show vitamin D may be beneficial for those with CF. More studies needed)
Grade of Evidence: Low quality of evidence
Vitamin K Supplement [12]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin k supplements are able to help treat cystic fibrosis. More studies needed)
Grade of Evidence: Very low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009
2. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/turmeric
3. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-turmeric.html
4. http://nccam.nih.gov/health/turmeric/index.htm
5. http://news.bbc.co.uk/2/hi/health/1668932.stm
6. http://www.mirror.co.uk/news/top-stories/2009/10/28/curry-kills-cancer-cells-and-other-health-benefits-of-the-nations-favourite-dish-115875-21779950/
7. http://clinicaltrials.gov/ct2/results?term=turmeric
8. http://www.ncbi.nlm.nih.gov/pubmed/22895955
9. http://www.ncbi.nlm.nih.gov/pubmed/24823922
10. http://www.hindawi.com/journals/ije/2010/218691/
11. http://www.ncbi.nlm.nih.gov/pubmed/22513949
12. http://www.ncbi.nlm.nih.gov/pubmed/11391328