Antispasmodic

An antispasmodic (synonym: spasmolytic) is a drug or an herb that suppresses spasms.^[1][2] These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.

Examples

Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. Both of these drugs have general side effects and can worsen gastroesophageal reflux disease.^[3]

Mebeverine, which is a muscolotropic spasmolytic with a strong and selective action on the smooth muscle spasm of the gastrointestinal tract, particularly of the colon. It does not have the anticholinergic side effect commonly seen in an anticholinergic antispasmodic.

Peppermint oil has been traditionally used as an antispasmodic, and a review of studies on the topic found that it "could be efficacious for symptom relief in IBS"^[4] (as an antispasmodic) although more carefully controlled studies are needed. A later study showed it is an effective antispasmodic when test-applied topically to the intestine during endoscopy.^[5]

The flower Liatris, also called blazing star, has also been used as an antispasmodic^{[citation needed]}. Another old common name for this plant is Colic Root, alluding to its medicinal use as an antispasmodic for the intestines.

Most forms of the strain of Marijuana Indica are a highly effective anti spasm agent.^{[citation needed]}

See also

• Muscarinic antagonist
• Parasympatholytic

References

External links

• MeSH Antispasmodics